1977•The Journal of Clinical Endocrinology & MetabolismRequires access

Comparison of Serum Calcitonin Levels After a 1-Minute Calcium Injection and After Pentagastrin Injection in the Diagnosis of Medullary Thyroid Carcinoma

Robert K. Rude, Frederick R. Singer

Abstract

A 1-min calcium injection was compared with a pentagastrin injection as provocative measures in stimulating calcitonin secretion in 4 patients with medullary thyroid carcinoma. In all cases the calcium injection resulted in a greater rise in serum calcitonin concentration. The patients tolerated the calcium injection well. However, two patients experienced substernal pressure and dyspnea following the pentagastrin injection. It is concluded that a 1-min calcium injection is a safe, rapid and effective procedure in the diagnosis of medullary thyroid carcinoma.

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Key concepts: Pentagastrin, Calcitonin, Medicine, Medullary cavity, Thyroid carcinoma, Calcium, Medullary carcinoma, Internal medicine