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2005•Psychosomatic MedicineRequires access

Hypercortisolemia and Depression

Charles F. Gillespie, Charles B. Nemeroff

Open publisher page 361 citations

Abstract

Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications. HPA = hypothalamic-pituitary-adrenal; DST = dexamethasone suppression test; ACTH = adrenocorticotropic hormone; NS = nonsuppression; CRF = corticotropin-releasing factor.

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What this paper is about

Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications. HPA = hypothalamic-pituitary-adrenal; DST = dexamethasone suppression test; ACTH = adrenocorticotropic hormone; NS = nonsuppression; CRF = corticotropin-releasing factor.

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OpenAlex reports 361 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Hypercortisolemia and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis are often found in severe forms of depression. The authors review the history of techniques used to assess the functions of the HPA axis, evidence for hypercortisolemia as a state rather than trait component of depression, and treatment implications. HPA = hypothalamic-pituitary-adrenal; DST = dexamethasone suppression test; ACTH = adrenocorticotropic hormone; NS = nonsuppression; CRF = corticotropin-releasing factor.

Key concepts: Hypercortisolemia, Depression (economics), Trait, Psychology, Anhedonia, Medicine, Neuroscience, Psychiatry

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