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1974•British Journal of Clinical PharmacologyOpen access

THE EFFECT OF PREDNISONE TREATMENT ON THE HALF‐LIFE OF INTRAVENOUS HYDROCORTISONE

Gillian M. Shenfield, James W. Paterson, J. F. Costello, O. Ijaduola

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Abstract

1 The half-life of hydrocortisone (cortisol) has been measured in six patients before and after a three-week course of prednisone given for asthma. 2 There was considerable variation in peak plasma level of cortisol both within and between patients, but on both occasions the plasma half-lives were the same. 3 It was concluded that short courses of prednisone have no effect on the handling of hydrocortisone.

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1 The half-life of hydrocortisone (cortisol) has been measured in six patients before and after a three-week course of prednisone given for asthma. 2 There was considerable variation in peak plasma level of cortisol both within and between patients, but on both occasions the plasma half-lives were the same. 3 It was concluded that short courses of prednisone have no effect on the handling of hydrocortisone.

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Available abstract

1 The half-life of hydrocortisone (cortisol) has been measured in six patients before and after a three-week course of prednisone given for asthma. 2 There was considerable variation in peak plasma level of cortisol both within and between patients, but on both occasions the plasma half-lives were the same. 3 It was concluded that short courses of prednisone have no effect on the handling of hydrocortisone.

Key concepts: Prednisone, Hydrocortisone, Medicine, Asthma, Corticosteroid, Internal medicine, Half-life, Endocrinology

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