1980•Journal of Pharmacobio-DynamicsOpen access

UDP-glucuronyltransferase activities of rabbit liver microsomes for cannabinoids.

Kazuhito Watanabe, Ikuo Yamamoto, Kazuta Oguri, Hidetoshi Yoshimura

Abstract

UDP-glucuronyltransferase activities for delta 8-tetrahydrocannabinol, 11-hydroxy-delta 8-tetrahydrocannabinol, cannabidiol and cannabinol were examined using liver microsomes of rabbits. The activities for cannabidiol and cannabinol were 2.5 and 19 times higher, respectively, than those for delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol. Thus, the present study supports the view that glucuronide formation plays an important role in the metabolism of cannabinol, but does only a minor role in that of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol.

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Key concepts: Cannabinol, Cannabidiol, Tetrahydrocannabinol, Chemistry, Microsome, Δ9-tetrahydrocannabinol, Pharmacology, Cannabinoid