2005•Epiliepsy currents/Epilepsy currentsOpen access

The Role of the Subiculum in Epilepsy and Epileptogenesis

Carl E. Stafstrom

Abstract

The subiculum is the first output structure distal to the hippocampus, abutting subfield CA1. As such, the subiculum receives afferent input from the hippocampus. Accumulating clinical and experimental evidence suggests that the subiculum plays an important role in the initiation and maintenance of epileptic discharges in temporal lobe epilepsy. This review discusses the anatomy and physiology of the subiculum and examines its participation in epilepsy and epileptogenesis.

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Key concepts: Subiculum, Epileptogenesis, Epilepsy, Neuroscience, Hippocampus, Afferent, Mesial temporal lobe epilepsy, Temporal lobe