2005•The Journal of DermatologyRequires access

Double‐Blind, Crossover Comparison of Olopatadine and Cetirizine versus Placebo: Suppressive Effects on Skin Response to Histamine Iontophoresis

Eishin Morita, Hiroaki Matsuo, Yan Zhang

Abstract

Olopathadine, a newly developed histamine H1-receptor antagonist, was compared with cetirizine in its suppressive effects on histamine-induced wheal and flare reaction using an iontophoresis technique in a double-blind, crossover, placebo-controlled fashion. As a result, olopathadine was found to have effects comparable to cetirizine. This finding may predict the efficacy of this new H1-antagonist in treating pruritic skin diseases.

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Key concepts: Cetirizine, Histamine, Crossover study, Histamine H1 receptor, Iontophoresis, Antagonist, Double blind, Medicine