2004•Bioorganic & Medicinal Chemistry LettersOpen access

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors

Christoph M. Schultes, Bérangère Guyen, Javier Cuesta, Stephen Neidle

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Key concepts: Telomerase, Telomere, Förster resonance energy transfer, Chemistry, G-quadruplex, Small molecule, DNA, Acridine

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Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors — Research Paper | ScholarLens