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1988•Journal of Neurology Neurosurgery & PsychiatryOpen access

Imaging of cerebral blood flow markers in Huntington's disease using single photon emission computed tomography.

Ian Reid, J. A. O. Besson, P. V. Best, Peter F. Sharp, H. G. Gemmell, F. W. Smith

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Abstract

Single photon emission computed tomography (SPECT) imaging of six Huntington's disease patients revealed a striking reduction in regional uptake of cerebral blood flow markers in vivo. Similar changes were found in one patient with "early stage" disease. The findings are compared with parallel magnetic resonance imaging (MRI) studies, and in one case, results of postmortem examination.

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Single photon emission computed tomography (SPECT) imaging of six Huntington's disease patients revealed a striking reduction in regional uptake of cerebral blood flow markers in vivo. Similar changes were found in one patient with "early stage" disease. The findings are compared with parallel magnetic resonance imaging (MRI) studies, and in one case, results of postmortem examination.

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Available abstract

Single photon emission computed tomography (SPECT) imaging of six Huntington's disease patients revealed a striking reduction in regional uptake of cerebral blood flow markers in vivo. Similar changes were found in one patient with "early stage" disease. The findings are compared with parallel magnetic resonance imaging (MRI) studies, and in one case, results of postmortem examination.

Key concepts: Single-photon emission computed tomography, Cerebral blood flow, Magnetic resonance imaging, Emission computed tomography, Preclinical imaging, Medicine, Blood flow, Positron emission tomography

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Imaging of cerebral blood flow markers in Huntington's disease using single photon emission computed tomography. — Research Paper | ScholarLens