1990•Annals of Clinical Biochemistry International Journal of Laboratory MedicineRequires access

Estimation of Paraproteins by Immunoturbidimetry and Electrophoresis Followed by Scanning Densitometry

David A. Sinclair, Fiona C. Ballantyne, Susan Shanley, Eleanor Caine, Denis StJ O'Reilly, Alan Shenkin

Abstract

A comparison of paraprotein estimation by immunoturbidimetry (IT) and electrophoresis followed by scanning densitometry (EFD) showed significant differences in concentration for IgG, IgA, and IgM paraproteins. Overestimation of IgM paraproteins by IT was particularly marked. Our data suggest that both techniques should be used for IgG and IgA paraproteins but for IgM paraproteins IT was found to be unsuitable and EFD is the method of choice.

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Key concepts: Paraproteins, Densitometry, Chemistry, Immunoglobulin A, Nephelometry, Chromatography, Immunology, Medicine