2007•BMC PharmacologyOpen access

Effects of vardenafil, a selective phosphodiesterase-5-inhibitor, on cardiovascular function in a rat model

Sivakkanan Loganathan, Tamás Radovits, Iwan R Wirotanseng, Gábor Veres, Siegfried Hagl, Gabor B. Szabo

Abstract

Background Phosphodiesterase-5-inhibitors are vasoactive drugs used in the treatment of erectile dysfunction and pulmonary hypertension. Their beneficial effects in the pulmonary vasculature are widely described, but it remained unclear, how they influence cardiac performance. In the present study we investigated the effects of the phosphodiesterase5-inhibitor vardenafil on myocardial and vasomotor function in a rat model.

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Available abstract

Key concepts: Vardenafil, cGMP-specific phosphodiesterase type 5, Pharmacology, Sildenafil, Tadalafil, Phosphodiesterase, Function (biology), Medicine