Convenient Syntheses of Racemic 2-(3-Nitrophenyl)propanoic Acid and 2-(3-Aminophenyl)propanoic Acid
Luc Grondard, Franco Manfré, Stéphane Mutti
Abstract
Luc Grondard, Franco Manfré, Stéphane Mutti
Abstract
2-(4-Chlorophenyl)propanoic acid 1 is transformed to 2-(4-chloro-3-nitrophenyl) propanoic acid 2 (94% yield). Acid 2 can be converted to 2-(3-nitrophenyl)propanoic acid 3 (70% yield) or to 2-(3-aminophenyl) propanoic acid 4 (80% yield).
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2-(4-Chlorophenyl)propanoic acid 1 is transformed to 2-(4-chloro-3-nitrophenyl) propanoic acid 2 (94% yield). Acid 2 can be converted to 2-(3-nitrophenyl)propanoic acid 3 (70% yield) or to 2-(3-aminophenyl) propanoic acid 4 (80% yield).
Key concepts: Propanoic acid, Chemistry, Yield (engineering), Organic chemistry, Stereochemistry, Materials science, Metallurgy