Abstract 2097A: The role of Lipocalin-2 in colorectal cancer metastasis

Abstract Colorectal cancer, the third leading cause of cancer deaths in America, has a poor clinical outcome once the disease has progressed to stage IV metastatic cancer. Five-year survivorship of stage IV is only 10%, but survivorship of stage I is drastically higher at 90%. Therefore, understanding the early stages of colorectal cancer metastasis is critical to develop therapeutic strategies for treating and preventing stage IV colorectal cancer. Using an orthotopic model for colorectal cancer metastasis, we have observed that our highly metastatic cell line produces a pre-metastatic upregulation of Lipocalin-2 both in circulation and in the liver. Overexpression of Lipocalin-2 in our highly metastatic cell line led to an overall reduction of circulating iron. Lipocalin-2 is upregulated in many primary tumors of epithelial origin, but the role of Lipocalin-2 in metastasis remains unclear. The full effects and implications of Lipocalin-2 in colorectal cancer metastasis remain to be elucidated. Citation Format: Daniel Titus Hughes. The role of Lipocalin-2 in colorectal cancer metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2097A. doi:10.1158/1538-7445.AM2014-2097A