ScholarLens Back to search
1977•Scandinavian Journal of HaematologyRequires access

Basophilic Differentiation of Chronic Myelogenous Leukaemia Cells in Vitro

Ichiro Miyoshi, Hiroshi Uchida, Teruhiko Tsubota, Ichiro Kubonishi, Shunkichi Hiraki, K Kitajima

Open publisher page 16 citations

Abstract

Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed in increased proportion of mature basophilis at about 3 weeks and most cultures consisted predominantly of mature basophilis at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.

About this research paper

What this paper is about

Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed in increased proportion of mature basophilis at about 3 weeks and most cultures consisted predominantly of mature basophilis at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.

Why it matters

OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed in increased proportion of mature basophilis at about 3 weeks and most cultures consisted predominantly of mature basophilis at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.

Key concepts: Basophilia, Basophilic, In vitro, Chronic myelogenous leukemia, Pathology, Biology, Immunology, Medicine

Related papers

Related paper 1Related paper 2
Back to paper searchBrowse research topicsOriginal source
Basophilic Differentiation of Chronic Myelogenous Leukaemia Cells in Vitro — Research Paper | ScholarLens