2012•Natural Product ResearchOpen access

Evaluation of the sedative and hypnotic effects of Eucommiol in Eucommia

Xin Li, Wenxue Zhu, Lipeng Yang, Dong‐Qing Fei, Jinling Fan, Lin Du, Yan Liu

Abstract

The purpose of this study was to evaluate the sedative and hypnotic effects of Eucommiol, a monomer compound extracted from male Eucommia flowers using a system solvent method. Eucommiol shows significant effects in mice, including reduced spontaneous activity, and increased the sleep ratio or lengthened the sleep time with a subthreshold or superthreshold dose of pentobarbital sodium, respectively. In addition, could effectively shorten sleep latency, reduce convulsion rate and prolong convulsion latency. These findings intensely indicated that Eucommiol has excellent sedative and hypnotic effects.

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Available abstract

Key concepts: Sedative, Hypnotic, Pentobarbital, Convulsion, Anesthesia, Pharmacology, Sleep (system call), Medicine