Effects of Orally Administered “Tween 80” on the Mesenteric Lymph Nodes of Intact and Adrenalectomized Mice

In this study, histological observations on the structural alterations caused in the mesenteric lymph nodes of young adult female mice after an oral administration of Tween 80 were presented. Some of the animals were preliminarily adrenalectomized, in order to prevent destructive influence of adrenal corticoids on the lymphatic tissue. A comparison between the changes observed in the mesenteric lymph nodes in both the groups of intact and adrenalectomized animals has led to the conclusion that Tween accerelates the release of lymphocytes from the parenchyma of the lymph nodes into the sinus, and besides, that Tween may possibly act destructively on the mature lymphocytes.