1970•Experimental Biology and MedicineRequires access

Effect of Immune Syngeneic Lymphoid Cells on Plating Efficiency of a Polyoma Virus-Induced Neoplasm

Nelson A. Burstein

Abstract

An in vitro technique for plating tumor cells with a high efficiency is described. BN rats were immunized to a syngeneic, cloned, tissue culture-adapted, polyoma-induced fibrosarcoma (BN SE3049) by amputation of a tumor-bearing extremity. Lymphoid cells from spleen and draining lymph nodes, but not serum, from these rats were effective in reducing the plating efficiency of the tumor. This finding is consistent with the necessary role of cellular immunity in resistance to polyoma oncogenesis.

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Key concepts: Plating efficiency, Fibrosarcoma, Neoplasm, Spleen, In vitro, Immune system, Carcinogenesis, Cancer research