1993•Fundamental and Clinical PharmacologyRequires access
Metabotropic glutamate receptors: an original family of G protein‐coupled receptors
Joël Bockaert, Jean‐Philippe Pin, Laurent Fagni
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Abstract
In 1985, we discovered a new glutamate receptor which was coupled to phospholipase C via a G protein and which was later termed metabotropic glutamate receptor (mGluR). In this review, both the diversity of mGluRs and the cellular events they control are discussed, as well as their roles in physiological regulation and brain function.