Michael additions to acrylonitrile, methyl acrylate and methyl vinyl ketone to Nb‐benzylidenetryptophan methyl ester
Miguel F. Braña, Mercedes Garrido, María L. López-Rodrı́guez, M. J. MORCILLO
Abstract
Miguel F. Braña, Mercedes Garrido, María L. López-Rodrı́guez, M. J. MORCILLO
Abstract
Abstract Michael addition to methyl acrylate and methyl vinyl ketone of Nb‐benzylidene‐L‐tryptophan methyl ester 1 gave 2‐(3‐indolylmethyl)glutamic dimethyl ester 2a and α‐(3‐oxobutyl)tryptophan methyl ester 2b respectively. Addition to acrylonitrile of 1 yielded α,Na‐dicyanoethyltryptophan methyl ester 3.
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Abstract Michael addition to methyl acrylate and methyl vinyl ketone of Nb‐benzylidene‐L‐tryptophan methyl ester 1 gave 2‐(3‐indolylmethyl)glutamic dimethyl ester 2a and α‐(3‐oxobutyl)tryptophan methyl ester 2b respectively. Addition to acrylonitrile of 1 yielded α,Na‐dicyanoethyltryptophan methyl ester 3.
Key concepts: Methyl vinyl ketone, Methyl acrylate, Acrylonitrile, Chemistry, Michael reaction, Vinyl ester, Ketone, Methyl Ketone