1987•FEBS LettersOpen access

Monoclonal antibody to fibronectin which inhibits extracellular matrix assembly

Michael A. Chernousov, Alexander Faerman, Maria G. Frid, Olga Yu. Printseva, V.E. Koteliansky

Abstract

A monoclonal antibody L8 specific to fibronectin was shown to inhibit fibronectin incorporation into the fibroblast extracellular matrix. Antibody L8 could not interact with fibronectin complexed with gelatin. The results suggest the existence of a specific site on the fibronectin molecule playing a critical role in the assembly of the fibronectin extracellular matrix. This site is located near the collagen-binding domain.

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Key concepts: Fibronectin, Extracellular matrix, Monoclonal antibody, Chemistry, Fibronectins, Matrix (chemical analysis), Fibroblast, Extracellular