The Phagocytosis‐Associated Chemotaxis of Human Mononuclear Leucocytes from Peripheral Blood is not Antitubulin‐Sensitive
Lars Rydgren, Bo Norberg, Björn Svensson, G. SIMMINGSKOELD
Abstract
Lars Rydgren, Bo Norberg, Björn Svensson, G. SIMMINGSKOELD
Abstract
Lymphoprep-isolated and glass-adherent mononuclear leucocytes (L-MNs) from the peripheral blood of healthy donors appeared to display directional locomotion towards sparsely distributed yeast cells during continuous observation in coverslip preparations and during observations by means of time-lapse filming in Rose chambers. The phagocytosis-associated L-MN chemotaxis was not inhibited by antitubulin concentrations which were antichemotactic thesis that a direct antitubulin-insensitive chemotaxis exists in L-MNs, besides the antitubulin-inhibited L-MN chemoataxis reported in a previous study.
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Lymphoprep-isolated and glass-adherent mononuclear leucocytes (L-MNs) from the peripheral blood of healthy donors appeared to display directional locomotion towards sparsely distributed yeast cells during continuous observation in coverslip preparations and during observations by means of time-lapse filming in Rose chambers. The phagocytosis-associated L-MN chemotaxis was not inhibited by antitubulin concentrations which were antichemotactic thesis that a direct antitubulin-insensitive chemotaxis exists in L-MNs, besides the antitubulin-inhibited L-MN chemoataxis reported in a previous study.
Key concepts: Chemotaxis, Phagocytosis, Peripheral blood mononuclear cell, Peripheral blood, Chemotaxis assay, Cell biology, Biology, Immunology