1988•Antimicrobial Agents and ChemotherapyOpen access

In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin

A L Barry, Ronald N. Jones, C Thornsberry

Abstract

The in vitro activity of azithromycin (CP 62,993 or XZ-450) against Haemophilus influenzae was greater than that of three other macrolides. However, azithromycin was four- to eightfold less active than erythromycin against the gram-positive cocci and against Listeria monocytogenes. Erythromycin and azithromycin were similar in their activity against Legionella pneumophila, Neisseria gonorrhoeae, Neisseria meningitidis, and Branhamella catarrhalis.

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Available abstract

Key concepts: Roxithromycin, Azithromycin, Microbiology, Erythromycin, Clarithromycin, Neisseria meningitidis, Haemophilus influenzae, Neisseria gonorrhoeae