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1967•British Journal of HaematologyRequires access

The Factor‐VIII Activity in Fresh and Stored Plasma

A. E. Preston

Open publisher page 29 citations

Abstract

SUMMARY An investigation into the Factor‐VIII activity in fresh and stored plasma is reported and the present methods of production at the Oxford Regional Blood Transfusion Centre described. Simple methods for increasing the Factor‐VIII activity of therapeutic plasma are suggested. Special equipment and methods did not prevent the loss of activity which occurs following the freezing, storage and thawing of fresh frozen plasma. A comparison between plasma stored at 4° C. for less than 18 hours is made with fresh frozen plasma and the use of the former is suggested for routine treatment of minor injuries when fresh frozen plasma is not available.

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SUMMARY An investigation into the Factor‐VIII activity in fresh and stored plasma is reported and the present methods of production at the Oxford Regional Blood Transfusion Centre described. Simple methods for increasing the Factor‐VIII activity of therapeutic plasma are suggested. Special equipment and methods did not prevent the loss of activity which occurs following the freezing, storage and thawing of fresh frozen plasma. A comparison between plasma stored at 4° C. for less than 18 hours is made with fresh frozen plasma and the use of the former is suggested for routine treatment of minor injuries when fresh frozen plasma is not available.

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Available abstract

SUMMARY An investigation into the Factor‐VIII activity in fresh and stored plasma is reported and the present methods of production at the Oxford Regional Blood Transfusion Centre described. Simple methods for increasing the Factor‐VIII activity of therapeutic plasma are suggested. Special equipment and methods did not prevent the loss of activity which occurs following the freezing, storage and thawing of fresh frozen plasma. A comparison between plasma stored at 4° C. for less than 18 hours is made with fresh frozen plasma and the use of the former is suggested for routine treatment of minor injuries when fresh frozen plasma is not available.

Key concepts: Fresh frozen plasma, Blood preservation, Plasma, Blood plasma, Blood transfusion, Chemistry, Medicine, Andrology

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