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2012•Acta OphthalmologicaRequires access

Experimental glaucoma models

Giedrius Kalesnykas

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Abstract

Abstract Purpose To introduce in vivo methods for experimental glaucoma research. Methods Animal models with natural elevation of intraocular pressure (IOP) and genetic manipulation to raise IOP will be discussed. Experimental elevation of IOP in rats and mice will be presented in more detail. Results Up to 30% of retinal ganglion cell (RGC) loss during a 3‐week period can be achieved with rat laser photocoagulation model. Similarly, experimental elevation of IOP in mice can result in up to 30% RGC axon loss in the optic nerve with a 6‐week follow‐up. Conclusion The age and strain of animals should be considered in experimental glaucoma research.

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What this paper is about

Abstract Purpose To introduce in vivo methods for experimental glaucoma research. Methods Animal models with natural elevation of intraocular pressure (IOP) and genetic manipulation to raise IOP will be discussed. Experimental elevation of IOP in rats and mice will be presented in more detail. Results Up to 30% of retinal ganglion cell (RGC) loss during a 3‐week period can be achieved with rat laser photocoagulation model. Similarly, experimental elevation of IOP in mice can result in up to 30% RGC axon loss in the optic nerve with a 6‐week follow‐up. Conclusion The age and strain of animals should be considered in experimental glaucoma research.

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Available abstract

Abstract Purpose To introduce in vivo methods for experimental glaucoma research. Methods Animal models with natural elevation of intraocular pressure (IOP) and genetic manipulation to raise IOP will be discussed. Experimental elevation of IOP in rats and mice will be presented in more detail. Results Up to 30% of retinal ganglion cell (RGC) loss during a 3‐week period can be achieved with rat laser photocoagulation model. Similarly, experimental elevation of IOP in mice can result in up to 30% RGC axon loss in the optic nerve with a 6‐week follow‐up. Conclusion The age and strain of animals should be considered in experimental glaucoma research.

Key concepts: Glaucoma, Intraocular pressure, Optic nerve, Ophthalmology, Retinal ganglion cell, Elevation (ballistics), Medicine, Experimental animal

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