2007•British Journal of HaematologyRequires access
Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B‐chronic lymphocytic leukaemia
Ludger Sellmann, Stefan Gesk, Christoph Walter, Matthias Ritgen, Lana L. Harder, José Ignacio Martín-Subero, Roland Schroers, Dörte Siemer, Holger Nückel, Martin J.S. Dyer, Ulrich Dührsen, Reiner Siebert, Jan Dürig, Ralf Küppers
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Abstract
The occurrence of trisomy 19 was investigated in 705 cases of B-chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1.6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B-CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells.