2008•Advanced Synthesis & CatalysisRequires access

Organocatalytic Highly Enantioselective Conjugate Addition of Aldehydes to Alkylidine Malonates

Gui‐Ling Zhao, Ján Veselý, Junliang Sun, Kirsten E. Christensen, Charlotte Bonneau, Armando Córdova

Abstract

Abstract The first highly enantioselective, direct organocatalytic conjugate addition of unmodified aldehydes to alkylidinemalonates is presented. The reaction gives access to β‐formyl‐substituted malonates and highly functionalized lactones with up to 14:1 dr and generally 94 to >99% ee.

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Available abstract

Key concepts: Enantioselective synthesis, Chemistry, Conjugate, Organocatalysis, Organic chemistry, Addition reaction, Catalysis, Combinatorial chemistry