Case 21-1997: Paraneoplastic Cerebellar Degeneration and Hodgkin's Disease

To the Editor: Dr. Eder, in his discussion of the paraneoplastic cerebellar degeneration associated with Hodgkin's disease (July 10 issue),1 quoted the 1976 paper by Trotter and colleagues2 but did not mention that the antibodies they described are now recognized as distinct antibodies associated with Hodgkin's disease. These antibodies have been designated anti-Tr antibodies.3 They have a characteristic dotted staining pattern, suggestive of immunoreactivity of the dendritic spines of Purkinje cells, and are specific for Hodgkin's disease.