ScholarLens Back to search
1971•Journal of EndocrinologyRequires access

THE ROLE OF PROLACTIN IN THE REGULATION OF TESTICULAR FUNCTION: THE EFFECT OF PROLACTIN AND LUTEINIZING HORMONE ON 3β-HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN THE TESTES OF MICE AND RATS

A. A. Hafiez, John Philpott, Andrzej Bartke

Open publisher page 71 citations

Abstract

SUMMARY Administration of 100 μg prolactin twice daily for 3 days increased 3β-hydroxysteroid dehydrogenase (3β-HSD) activity in the testes of dwarf mice compared with that found in the normal mouse. In hypophysectomized rats, prolactin (200 μg, same regimen) was without effect when given alone, whereas 5 μg luteinizing hormone (LH) alone injected twice daily, increased 3β-HSD activity to above normal. When prolactin and LH were administered in combination, 3β-HSD activity was raised to normal levels only.

About this research paper

What this paper is about

SUMMARY Administration of 100 μg prolactin twice daily for 3 days increased 3β-hydroxysteroid dehydrogenase (3β-HSD) activity in the testes of dwarf mice compared with that found in the normal mouse. In hypophysectomized rats, prolactin (200 μg, same regimen) was without effect when given alone, whereas 5 μg luteinizing hormone (LH) alone injected twice daily, increased 3β-HSD activity to above normal. When prolactin and LH were administered in combination, 3β-HSD activity was raised to normal levels only.

Why it matters

OpenAlex reports 71 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

SUMMARY Administration of 100 μg prolactin twice daily for 3 days increased 3β-hydroxysteroid dehydrogenase (3β-HSD) activity in the testes of dwarf mice compared with that found in the normal mouse. In hypophysectomized rats, prolactin (200 μg, same regimen) was without effect when given alone, whereas 5 μg luteinizing hormone (LH) alone injected twice daily, increased 3β-HSD activity to above normal. When prolactin and LH were administered in combination, 3β-HSD activity was raised to normal levels only.

Key concepts: Prolactin, Internal medicine, Endocrinology, Luteinizing hormone, Hormone, Hydroxysteroid dehydrogenase, Dehydrogenase, Prolactin cell

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
THE ROLE OF PROLACTIN IN THE REGULATION OF TESTICULAR FUNCTION: THE EFFECT OF PROLACTIN AND LUTEINIZING HORMONE ON 3β-HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN THE TESTES OF MICE AND RATS — Research Paper | ScholarLens