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Atropine Sulfate vs Atropine Methyl Bromide

Constante B. dePadua

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Abstract

Effects of atropine sulfate and atropine methyl bromide on maternal and fetal heart rates were observed in 12 women at term. Both drugs were given in graded doses to a total dose of 0.8 mg/70 kg body weight. Both drugs caused significant acceleration of the mothers' heart rates, but only atropine sulfate accelerated fetal heart rates. We assume that atropine methyl bromide, because of its charge, did not penetrate the placental barrier as readily as atropine sulfate.

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What this paper is about

Effects of atropine sulfate and atropine methyl bromide on maternal and fetal heart rates were observed in 12 women at term. Both drugs were given in graded doses to a total dose of 0.8 mg/70 kg body weight. Both drugs caused significant acceleration of the mothers' heart rates, but only atropine sulfate accelerated fetal heart rates. We assume that atropine methyl bromide, because of its charge, did not penetrate the placental barrier as readily as atropine sulfate.

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Available abstract

Effects of atropine sulfate and atropine methyl bromide on maternal and fetal heart rates were observed in 12 women at term. Both drugs were given in graded doses to a total dose of 0.8 mg/70 kg body weight. Both drugs caused significant acceleration of the mothers' heart rates, but only atropine sulfate accelerated fetal heart rates. We assume that atropine methyl bromide, because of its charge, did not penetrate the placental barrier as readily as atropine sulfate.

Key concepts: Medicine, Atropine, Atropine sulfate, Bromide, Sulfate, Anesthesia, Pharmacology, Organic chemistry

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