2009•Current Pediatric ReviewsRequires access

Neonatal Persistent Pulmonary Hypertension Associated with Congenital Cystic Adenomatoid Malformation Treated with Sildenafil: Case Report

G Maffei, Vincenzo Manuppelli, R Magaldi

Abstract

We report a case with severe persistent pulmonary hypertension (PPHN) associated with congenital cystic adenomatoid malformation of the lung (CCAM) treated with sildenafil PO. The case was unresponsive to the High-Frequency Oscillatory Ventilation (HFOV), with a oxygenation index (OI) of 50 before sildenafil. Substantial improvement in OI was followed by extubation and survival. No side-effects were noted. Keywords: PPHN, CCAM, sildenafil, HFOV, oxygenation index

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Key concepts: Sildenafil, Medicine, Persistent pulmonary hypertension, Congenital Cystic Adenomatoid Malformation, Pulmonary hypertension, Oxygenation, Oxygenation index, Lung