Glomus tumours of the skin: an immunohistochemical investigation of the expression of marker proteins
Wolfgang Herbst, Kan‐ichiro Nakayama, O. P. Hornstein
Abstract
Wolfgang Herbst, Kan‐ichiro Nakayama, O. P. Hornstein
Abstract
Immunohistochemical studies were carried out on cutaneous glomus tumours from 10 patients. The glomus areas in these tumours reacted strongly with anti-smooth muscle (CGA-7), anti-muscle (HHF-35) and anti-vimentin antibodies. Their neural supply was analysed using several nervous tissue markers (anti-neurone specific enolase, anti-S 100, anti-Leu 7, anti-neurofilaments). The results indicate a sprouting and proliferation rather than entrapment of pre-existing nerve fibres.
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Immunohistochemical studies were carried out on cutaneous glomus tumours from 10 patients. The glomus areas in these tumours reacted strongly with anti-smooth muscle (CGA-7), anti-muscle (HHF-35) and anti-vimentin antibodies. Their neural supply was analysed using several nervous tissue markers (anti-neurone specific enolase, anti-S 100, anti-Leu 7, anti-neurofilaments). The results indicate a sprouting and proliferation rather than entrapment of pre-existing nerve fibres.
Key concepts: Immunohistochemistry, Enolase, Pathology, Neurofilament, Vimentin, Sprouting, Glomus, Glomus cell