Philip L. Hentall, Nadine Flowers, Timothy D. H. Bugg
Abstract
A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5-20 fold) and in a reduced dinucleotide coenzyme (2-3 fold), while retaining reactivity towards hydride transfer.
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A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5-20 fold) and in a reduced dinucleotide coenzyme (2-3 fold), while retaining reactivity towards hydride transfer.
Key concepts: Nicotinamide, Nicotinamide adenine dinucleotide, Chemistry, Cofactor, Substituent, NAD+ kinase, Reactivity (psychology), Hydride