2009•International Archives of Allergy and Applied ImmunologyRequires access

Lymphocyte-Mediated Cytotoxicity and Humoral Antibodies in Human Pregnancy

Xavier Chardonnens, Michel Jeannet

Abstract

Lymphocyte-mediated cytotoxicity, antibody-dependent cell cytotoxicity and complement-dependent antibody assays were used to study maternal immune response to fetal antigens present on cord lymphocytes at delivery. Among 24 cell-mediated lympholysis tests, 4 were found slightly positive and accompanied by a complement-dependent antibody and/or an antibody-dependent cell cytotoxicity response. The humoral immune response was found more often positive than the cellular response.

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Available abstract

Key concepts: Cytotoxicity, Antibody-dependent cell-mediated cytotoxicity, Immunology, Immune system, Antibody, Lymphocyte, Antigen, Biology