1980•Annals of Internal MedicineRequires access
Regimens for Treatment of Lupus Nephritis
David S. Kaplan
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Letters1 March 1980Regimens for Treatment of Lupus NephritisDAVID KAPLAN, M.D.DAVID KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-3-437_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his discussion in the National Institutes of Health conference "Systemic Lupus Erythematosus: Evolving Concepts" (1), Dr. Klippel compares several regimens for the treatment of lupus nephritis: unspecified but modest amounts of prednisone with either azathioprine, cyclophosphamide, azathioprine plus cyclophosphamide, or itermittent intravenous cyclophosphamide, and modest amounts of prednisone alone. He concludes that azathioprine plus cyclophosphamide and intravenous cyclophosphamide may "reduce the progression of renal disease" in patients with systemic lupus erythematosus.His data, however, may be organized as in Table 1, which considers only the preservation of renal function and suggests the following conclusions: cytotoxic drugs...References1. KLIPPEL J. Studies in the treatment of lupus nephritis, in DECKER JL. moderator. Systemic lupus erythematosus: evolving concepts. Ann Intern Med. 1979;91:587-604. LinkGoogle Scholar2. KAPLAN D. Treatment of systemic lupus erythematosus. Arthritis Rheum. 1977;20:S175-80. Google Scholar3. ALBERTHADLERROPES DNM. Does corticosteroid therapy affect the course of patients with systemic lupus erythematosus? Arthritis Rheum. 1979;22:945-53. CrossrefMedlineGoogle Scholar1. KLIPPEL J. Studies in the treatment of lupus nephritis, in DECKER JL, moderator. Systemic lupus erythematosus: evolving concepts. Ann Intern Med. 1979;91:587-604. LinkGoogle Scholar2. DONADIOHOLLEYFERGUSONILSTRUP JKRD. Treatment of diffuse proliferative lupus nephritis with prednisone and combined prednisone and cyclophosphamide. N Engl J Med. 1978;299:1151-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID KAPLAN, M.D.Affiliations: State University of New York Downstate Medical Center Brooklyn, NY 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical pharmacology and toxicology of cyclophosphamide: emphasis on use in rheumatic diseasesFortschritte in der Therapie des Lupus erythematodes 1 March 1980Volume 92, Issue 3Page: 437-438KeywordsCyclophosphamideDrugsLupus erythematosusLupus nephritisRenal diseases ePublished: 1 December 2008 Issue Published: 1 March 1980 PDF downloadLoading ...