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In Vitro Characterization of Bioactive Glasses

Di Zhang, Erik Vedel, Leena Hupa, Heimo O. Ylänen, Mikko M. Hupa

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Abstract

In vitro behavior of 30 new glasses in the system Na2O-K2O-MgO-CaO-B2O3 -P2O5-SiO2 was investigated by immersing them into a simulated body fluid for 4 to168 hours. This study involved the observation of both the changes in the properties of the immersion solution and on the glasses surface after immersion. In vitro reactivity was different for each experimental glass depending on its chemical composition. By comparing these glasses to four established bioactive glasses showing different in vivo bioactivity, a fast estimation of the bioactivity of glasses can be done; thereby the optimization of bioactive glasses for various clinical applications can be developed.

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What this paper is about

In vitro behavior of 30 new glasses in the system Na2O-K2O-MgO-CaO-B2O3 -P2O5-SiO2 was investigated by immersing them into a simulated body fluid for 4 to168 hours. This study involved the observation of both the changes in the properties of the immersion solution and on the glasses surface after immersion. In vitro reactivity was different for each experimental glass depending on its chemical composition. By comparing these glasses to four established bioactive glasses showing different in vivo bioactivity, a fast estimation of the bioactivity of glasses can be done; thereby the optimization of bioactive glasses for various clinical applications can be developed.

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OpenAlex reports 10 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In vitro behavior of 30 new glasses in the system Na2O-K2O-MgO-CaO-B2O3 -P2O5-SiO2 was investigated by immersing them into a simulated body fluid for 4 to168 hours. This study involved the observation of both the changes in the properties of the immersion solution and on the glasses surface after immersion. In vitro reactivity was different for each experimental glass depending on its chemical composition. By comparing these glasses to four established bioactive glasses showing different in vivo bioactivity, a fast estimation of the bioactivity of glasses can be done; thereby the optimization of bioactive glasses for various clinical applications can be developed.

Key concepts: Simulated body fluid, Bioactive glass, Materials science, Immersion (mathematics), In vitro, Characterization (materials science), In vivo, Chemical engineering

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