2008•Journal of Molecular BiologyRequires access

A Phosphorylation-Dependent Gating Mechanism Controls the SH2 Domain Interactions of the Shc Adaptor Protein

Roger George, Annika C. Schüller, Richard Harris, John E. Ladbury

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Key concepts: SH2 domain, Phosphotyrosine-binding domain, Proto-oncogene tyrosine-protein kinase Src, Phosphorylation, Signal transducing adaptor protein, GRB2, SH3 domain, Tyrosine

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