ScholarLens Back to search
1980•Acta Pharmacologica et ToxicologicaRequires access

Studies on thein VitroUptake of Polyamines by Girardi Heart Cells

Ingrid Alfheim, Jan K. Hongslo

Open publisher page 6 citations

Abstract

The uptake of spermine and spermidine in human heart cells in culture has been studied. Spermidine was accumulated to a higher degree than spermine whereas more spermine was absorbed to the cell surface. The results indicate that the uptake of spermidine and spermine is mediated by a common carrier. In addition, spermine enters the cells by several other transport mechanisms. The accumulated polyamines were not removed by washing with spermine or spermidine solutions, but they were released by treatment of the cells with butanol.

About this research paper

What this paper is about

The uptake of spermine and spermidine in human heart cells in culture has been studied. Spermidine was accumulated to a higher degree than spermine whereas more spermine was absorbed to the cell surface. The results indicate that the uptake of spermidine and spermine is mediated by a common carrier. In addition, spermine enters the cells by several other transport mechanisms. The accumulated polyamines were not removed by washing with spermine or spermidine solutions, but they were released by treatment of the cells with butanol.

Why it matters

OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The uptake of spermine and spermidine in human heart cells in culture has been studied. Spermidine was accumulated to a higher degree than spermine whereas more spermine was absorbed to the cell surface. The results indicate that the uptake of spermidine and spermine is mediated by a common carrier. In addition, spermine enters the cells by several other transport mechanisms. The accumulated polyamines were not removed by washing with spermine or spermidine solutions, but they were released by treatment of the cells with butanol.

Key concepts: In vitro, Chemistry, Biochemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Studies on thein VitroUptake of Polyamines by Girardi Heart Cells — Research Paper | ScholarLens