Sterol biosynthesis in the oyster,Crassostrea virginica
Shin‐ichi Teshima, Glenn W. Patterson
Abstract
Shin‐ichi Teshima, Glenn W. Patterson
Abstract
Abstract Sterol biosynthesis in the oyster,Crassostrea virginica, was examined by injection of [2‐14C]acetate and [2,3‐3H] lanosterol. The oyster incorporated [2‐14C] acetate into squalene 4,4′‐dimethylsterols, 4‐monomethylsterols, cholesterol, desmosterol, isofucosterol, and 24‐methylenecholesterol, and also converted [2‐3H] lanosterol to cholesterol. Therefore, the oyster was concluded to synthesize cholesterol, desmosterol, isofucosterol, and 24‐methylenecholesterol from acetate via squalene, probably using the lanosterol pathway.
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Abstract Sterol biosynthesis in the oyster,Crassostrea virginica, was examined by injection of [2‐14C]acetate and [2,3‐3H] lanosterol. The oyster incorporated [2‐14C] acetate into squalene 4,4′‐dimethylsterols, 4‐monomethylsterols, cholesterol, desmosterol, isofucosterol, and 24‐methylenecholesterol, and also converted [2‐3H] lanosterol to cholesterol. Therefore, the oyster was concluded to synthesize cholesterol, desmosterol, isofucosterol, and 24‐methylenecholesterol from acetate via squalene, probably using the lanosterol pathway.
Key concepts: Lanosterol, Desmosterol, Squalene, Oyster, Crassostrea, Sterol, Biochemistry, Cholesterol