Clinicopathological Correlation in Asian Patients with Biopsy-Proven Lupus Nephritis
Bancha Satirapoj, Pamila Tasanavipas, Ouppatham Supasyndh
Abstract
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Bancha Satirapoj, Pamila Tasanavipas, Ouppatham Supasyndh
Abstract
Open-access reader
A total of 244 patients with lupus nephritis (219 women (89.8%) with a female to male ratio of 9 : 1) were included in the study. Clinical and laboratory findings at renal biopsy are clinically valuable in identifying different renal classifications of lupus pathology, activity, and chronicity index. Patients with class IVG had significantly higher proportions of microscopic hematuria, proteinuria, hypertension, impaired renal function, anemia, hypoalbuminuria, and positive anti-DNA antibody. All of these findings correlated well with high activity index and chronicity index of lupus pathology. Considering these correlations may help to determine the clinicopathologic status of lupus patients.
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A total of 244 patients with lupus nephritis (219 women (89.8%) with a female to male ratio of 9 : 1) were included in the study. Clinical and laboratory findings at renal biopsy are clinically valuable in identifying different renal classifications of lupus pathology, activity, and chronicity index. Patients with class IVG had significantly higher proportions of microscopic hematuria, proteinuria, hypertension, impaired renal function, anemia, hypoalbuminuria, and positive anti-DNA antibody. All of these findings correlated well with high activity index and chronicity index of lupus pathology. Considering these correlations may help to determine the clinicopathologic status of lupus patients.
Key concepts: Medicine, Lupus nephritis, Renal pathology, Renal biopsy, Systemic lupus erythematosus, Proteinuria, Biopsy, Internal medicine