1973•The Japanese Journal of PharmacologyOpen access

STUDIES ON THE FUNCTION OF CELL MEMBRANE 4thREPORT : ELECTRON MICROSCOPIC OBSERVATIONS ON CHANGES IN ULTRA-STRUCTURE OF LIVER CELL MEMBRANES IN CCl4-TREATED RATS

Ichiro Yano, Yasusuke MASUDA, Masato Kuchii, Hiroyuki Yamamoto, Tadashi MURANO

Abstract

Morphological changes of liver cell membranes in CCl4-administered rats were observed electronmicroscopically by using mainly a negative staining method. CCl4 caused not only disappearance of elementary particles attached to the surface of cell membranes, but also that of hexagonal subunit patterns (treated with 1 % DOC) in the membranes of tight junction 3–6 hr after administration. Present data indicates that CCl4 primarily affects the plasma membrane rather than endoplasmic reticulum.

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Key concepts: Membrane, Endoplasmic reticulum, CCL4, Cell membrane, Cell, Biophysics, Chemistry, Staining