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Realizing the potential of zebrafish as a model for human disease

Bruce Barut, Leonard I. Zon

Open publisher page 94 citations

Abstract

Barut, Bruce A., and Leonard I. Zon. Realizing the potential of zebrafish as a model for human disease. Physiol Genomics 2: 49–51, 2000.—The value of the zebrafish ( Danio rerio) as a model for human disease has been substantiated by a number of recently published papers. Several zebrafish mutants with “human” diseases have been found, spanning a variety of human pathologies. These successful studies utilizing the zebrafish have been made possible by the development of key reagents such as YAC, PAC, and BAC libraries, as well as radiation hybrid panels. With the further establishment of new tools and access to the newly generated resources, the zebrafish is poised to serve as a novel model for human disease.

About this research paper

What this paper is about

Barut, Bruce A., and Leonard I. Zon. Realizing the potential of zebrafish as a model for human disease. Physiol Genomics 2: 49–51, 2000.—The value of the zebrafish ( Danio rerio) as a model for human disease has been substantiated by a number of recently published papers. Several zebrafish mutants with “human” diseases have been found, spanning a variety of human pathologies. These successful studies utilizing the zebrafish have been made possible by the development of key reagents such as YAC, PAC, and BAC libraries, as well as radiation hybrid panels. With the further establishment of new tools and access to the newly generated resources, the zebrafish is poised to serve as a novel model for human disease.

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OpenAlex reports 94 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Barut, Bruce A., and Leonard I. Zon. Realizing the potential of zebrafish as a model for human disease. Physiol Genomics 2: 49–51, 2000.—The value of the zebrafish ( Danio rerio) as a model for human disease has been substantiated by a number of recently published papers. Several zebrafish mutants with “human” diseases have been found, spanning a variety of human pathologies. These successful studies utilizing the zebrafish have been made possible by the development of key reagents such as YAC, PAC, and BAC libraries, as well as radiation hybrid panels. With the further establishment of new tools and access to the newly generated resources, the zebrafish is poised to serve as a novel model for human disease.

Key concepts: Zebrafish, Danio, Human disease, Biology, Model organism, Computational biology, Disease, Genomics

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