Steroid Hormone Receptor Families

Abstract The sections in this article are: Molecular Composition of Receptor Proteins: Primary Structural Homologies and Functional Domains The A/B Region of Steroid Receptors Contains a Hormone‐Independent Activation Function The C Region Encodes a Specific DNA‐Binding Function The D Region (the Hinge Domain) Contains a Nuclear Localization Signal The E/F Region Contains the Hormone‐Binding Domain, a Dimerization Motif, Steroid Receptor Repressor Activity, and a Receptor Agonist‐Dependent Transcriptional Activation Function Receptor‐Associated Proteins and the Oligomeric Structure of Steroid Receptors Major Heat Shock Proteins Cross‐Talk with Other Signal‐Transduction Pathways Cyclic Adenosine Monophosphate and Activation of Steroid Receptors Transcriptional Interference Pathways That Converge on the Estrogen Receptor Role of Phosphorylation in Steroid Receptor Structure and Function Sites of Phosphorylation, Functional Significance, and Regulatory Kinases Estrogen Receptor Phosphorylation Progesterone Receptor Phosphorylation Glucocorticoid Receptor Phosphorylation Vitamin D Receptor Phosphorylation Transactivation by Steroid Receptors Antihormones and Their Modes of Action RU486, an Agonist/Antagonist of Progesterone Receptor ZK98299, a Full Antagonist of Progesterone Receptor Antiestrogens and Estrogen Receptor Function Steroid Receptors and Clinical Management of Cancer Cancer: Molecular Aspects Breast Cancer, Tumor Suppressors, and Estrogen Paradoxical Effects of Estrogen: Molecular Aspects Future Directions