2005•PubMedRequires access

Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies.

Francesco Forconi, Donatella Raspadori, Mariapia Lenoci, Francesco Lauria

Abstract

Surface expression of CD27 was evaluated in 75 mature leukemic B-cell neoplasms. All cases other than hairy cell leukemia (HCL) expressed CD27. Intensity was significantly higher in chronic lymphocytic leukemia. Lack of CD27 in 17/17 HCL contrasted with expression of this marker in 5/5 splenic lymphomas with villous lymphocytes. Lack of CD27 is a new distinctive feature of HCL among B-cell malignancies.

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Key concepts: Hairy cell leukemia, Hairy Cell, Chronic lymphocytic leukemia, Leukemia, Surface Immunoglobulin, Cell, B cell, Cancer research