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2015•Clinical Cancer ResearchOpen access

Stroma, Stroma Everywhere (Far More Than You Think)

Kenneth P. Olive

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Abstract

Abstract Pancreatic ductal adenocarcinomas with high stromal content are shown to have greatly reduced overall survival, consistent with previous reports that stroma may limit drug delivery. In contrast to expectations, metastatic lesions were found to harbor as much stroma as primary tumors. Clin Cancer Res; 21(15); 3366–8. ©2015 AACR. See related article by Whatcott et al., p. 3561

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What this paper is about

Abstract Pancreatic ductal adenocarcinomas with high stromal content are shown to have greatly reduced overall survival, consistent with previous reports that stroma may limit drug delivery. In contrast to expectations, metastatic lesions were found to harbor as much stroma as primary tumors. Clin Cancer Res; 21(15); 3366–8. ©2015 AACR. See related article by Whatcott et al., p. 3561

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Available abstract

Abstract Pancreatic ductal adenocarcinomas with high stromal content are shown to have greatly reduced overall survival, consistent with previous reports that stroma may limit drug delivery. In contrast to expectations, metastatic lesions were found to harbor as much stroma as primary tumors. Clin Cancer Res; 21(15); 3366–8. ©2015 AACR. See related article by Whatcott et al., p. 3561

Key concepts: Stroma, Stromal cell, Pathology, Biology, Medicine, Immunohistochemistry

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