2010•PubMedRequires access

[Inappropriate antidiuretic hormone secretion induced by sodium valproate].

E Bève, Emmanuel Beck, Eveni Samilly Sales Pinto, M. Ansseau

Abstract

The occurrence of a syndrome of inappropriate antidiuretic hormone secretion (SIADH) with sodium valproate has been rarely described in the literature. We present a 46-year-old patient, admitted to the Emergency Room for confusion and acute agitation. The exploration showed a severe hyponatraemia induced by sodium valproate, prescribed for a type I bipolar disorder. This article addresses both somatic and psychiatric issues in the differential diagnosis of confusion and agitation.

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Key concepts: Confusion, Antidiuretic, Hyponatremia, Syndrome of inappropriate antidiuretic hormone secretion, Medicine, Sodium, Valproic Acid, Hormone