7Sgamma-1 and 7Sgamma-2 antibody response in the mouse. I. Influence of strain, antigen and adjuvant.

Summary The qualitative aspects of the 7S antibody response in the mouse have been studied using radio-immunoelectrophoresis. The production of a fast gamma (7S γ1 ) and/or a slow gamma (7S γ2 ) antibody was influenced by four separate factors: the antigen, the adjuvant, the strain of mouse and the previous exposure of the mouse to the antigen. A sequence of 7S antibody production was detected in certain circumstances and characterized by an initial antibody consisting of fast γ (7S γ1 )-, and a later antibody of slow γ (7S γ2 )-globulin.