1988•Infection and ImmunityOpen access

Levels of Listeria monocytogenes hemolysin are not directly proportional to virulence in experimental infections of mice

Sophia Kathariou, J. Rocourt, Herbert Hof, Werner Goebel

Abstract

The sulfhydryl-activated hemolysin of Listeria monocytogenes has been implicated in the virulence of the bacteria. Although loss of hemolytic activity by means of transposon mutagenesis is accompanied by loss of virulence in the mouse infection model, a direct relationship between in vitro production of hemolysin and virulence was not observed. Noticeable deviations in the extent of hemolysin production appeared to leave virulence unaffected.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 60 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Virulence, Listeria monocytogenes, Hemolysin, Biology, Microbiology, Listeria, Mutagenesis, Transposon mutagenesis