1974•Journal of Biological ChemistryOpen access

A New Dihydrofolate Reductase with Low Trimethoprim Sensitivity Induced by an R Factor Mediating High Resistance to Trimethoprim

Ola Sköld, Angela Widh

Abstract

An enzymic mechanism different from those described earlier is demonstrated for the insensitivity to antibiotics carried by R factors.An R plasmid carrying resistance to high levels of the folic acid analog, trimethoprim, was shown to induce highly increased levels of dihydrofolate reductase activity in sensitive cells of Escherichio coti.

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Key concepts: Dihydrofolate reductase, Trimethoprim, Folic Acid Antagonists, Folic acid, Plasmid, Antibiotics, Microbiology, Chemistry