2004•PubMedRequires access

The effects of hydroxyurea on PRV-1 expression in patients with essential thrombocythemia and polycythemia vera.

Peter Johansson, Anne Ricksten, Carina Wasslavik, Berit Johansson, Björn Andréasson

Abstract

The study was designed to investigate the influence of hydroxyurea (HU) treatment on PRV-1 expression. Eighteen newly diagnosed patients with essential thrombocythemia (ET) or polycythemia vera (PV) were included. HU significantly increased PRV-1 gene expression in the early stage of treatment.

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Key concepts: Essential thrombocythemia, Polycythemia vera, Medicine, Polycythemia rubra vera, Internal medicine, Hydroxycarbamide, Gastroenterology, Hematology