운동과 고혈압 : 운동에 의한 산화질소 생성과 혈관확장에 대한 종설

Hypertension is an independent risk factor for coronary artery disease and associated with endothelial dysfunction. Endothelium-derived relaxation factors (EDRF) including nitric oxide (NO) are reduced bioavailability in hypertension and cause increased agonist-induced vasoconstriction. Recently studies, regular exercise has been shown to improve endothelium function via various mechanical change as a shear stress and cell signal transduction in hypertensive animal model and in patients with hypertension. In addition, hydrogen peroxide (H₂O₂) and adiponectin independently lead to vasodilation and increasing endothelium nitric oxide synthase. H₂O₂ activates K? channel either by direct regulation of the channels or increase of endothelial nitric oxide synthease (eNOS). Hypodiponectinemia is associated with impaired endothelium-dependent vasodilation, which indicate reduced vasodilation. This review summarizes the current information on the improvement of NO bioavailability by regular exercise in hypertensive animal models and hypertensive patient.