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2012•Archives of Disease in ChildhoodRequires access

Interferon- release assays for the diagnosis of tuberculosis in children

M. Tebruegge, T. G. Connell, Nicole Ritz, Nigel Curtis

Open publisher page 2 citations

Abstract

We read with interest the recent publication by Mendez-Echevarria et al which compared the performance of tuberculin skin tests (TST) with a commercial interferon-γ release assay (IGRA), the QuantiFERON-TB Gold In-Tube assay, for the diagnosis of latent tuberculosis infection (LTBI) and active TB disease (TBD) in children.1 However, we believe several aspects require clarification for readers. Consistent with previous studies evaluating TST and IGRA in children, a significant proportion (4.4%) of participants had indeterminate IGRA results and an even higher proportion (8.9%) had discordant results, which were predominately (38/41; 92.7%) TST+/IGRA−.2 Interestingly, almost all (67/68; 98.5%) children with TBD had concordantly positive …

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What this paper is about

We read with interest the recent publication by Mendez-Echevarria et al which compared the performance of tuberculin skin tests (TST) with a commercial interferon-γ release assay (IGRA), the QuantiFERON-TB Gold In-Tube assay, for the diagnosis of latent tuberculosis infection (LTBI) and active TB disease (TBD) in children.1 However, we believe several aspects require clarification for readers. Consistent with previous studies evaluating TST and IGRA in children, a significant proportion (4.4%) of participants had indeterminate IGRA results and an even higher proportion (8.9%) had discordant results, which were predominately (38/41; 92.7%) TST+/IGRA−.2 Interestingly, almost all (67/68; 98.5%) children with TBD had concordantly positive …

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Available abstract

We read with interest the recent publication by Mendez-Echevarria et al which compared the performance of tuberculin skin tests (TST) with a commercial interferon-γ release assay (IGRA), the QuantiFERON-TB Gold In-Tube assay, for the diagnosis of latent tuberculosis infection (LTBI) and active TB disease (TBD) in children.1 However, we believe several aspects require clarification for readers. Consistent with previous studies evaluating TST and IGRA in children, a significant proportion (4.4%) of participants had indeterminate IGRA results and an even higher proportion (8.9%) had discordant results, which were predominately (38/41; 92.7%) TST+/IGRA−.2 Interestingly, almost all (67/68; 98.5%) children with TBD had concordantly positive …

Key concepts: Medicine, Tuberculin, Latent tuberculosis, Interferon γ, Interferon gamma release assay, Tuberculosis, QuantiFERON, Immunology

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